Gene Tests in Sudden Cardiac Death Victims Jamaica Plain MA

Genetic testing of people who've suffered sudden unexplained death is an effective and cost-efficient way of identifying genetic mutations that may put surviving relatives at increased risk for potentially deadly heart rhythm disturbances, a new study suggests.

Sonya Mariam Vaziri, MD
(617) 421-6050
45 Holbrook St
Jamaica Plain, MA
Specialties
Cardiology
Gender
Female
Education
Medical School: Vanderbilt Univ Sch Of Med, Nashville Tn 37232
Graduation Year: 1985

Data Provided by:
Alberto Ramirez
(617) 522-6010
1153 Centre St
Jamaica Plain, MA
Specialty
Cardiology

Data Provided by:
G Brandon Atkins, MD, PHD
(617) 726-9292
29 Cerdan Ave
Roslindale, MA
Specialties
Cardiology
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
Barbara Jo Trockman, MD
(781) 721-7256
49 Robinwood Ave
Boston, MA
Specialties
Cardiology
Gender
Female
Education
Medical School: Univ Of Hi John A Burns Sch Of Med, Honolulu Hi 96822
Graduation Year: 1977

Data Provided by:
Joseph Michael Garasic, MD
(617) 726-0712
28 Beaufort Rd
Jamaica Plain, MA
Specialties
Cardiology
Gender
Male
Education
Medical School: Boston Univ Sch Of Med, Boston Ma 02118
Graduation Year: 1994

Data Provided by:
Manish Hasmukh Shah, MD
105 Fletcher St Fl 1
Roslindale, MA
Specialties
Cardiology
Gender
Male
Education
Medical School: Case Western Reserve Univ Sch Of Med, Cleveland Oh 44106
Graduation Year: 2000

Data Provided by:
Charles Joseph Vaughan, MD
150 S Huntington Ave
Boston, MA
Specialties
Cardiology
Gender
Male
Education
Medical School: Univ Coll Of Cork, Nat'L Univ Of Ireland, Fac Of Med, Cork
Graduation Year: 1989

Data Provided by:
Gary Brockington
(617) 522-5800
1153 Centre St
Jamaica Plain, MA
Specialty
Cardiology, Internal Medicine

Data Provided by:
Ronald Paul Pigeon, MD
(617) 325-4445
19 Cornell St
Roslindale, MA
Specialties
Cardiology
Gender
Male
Education
Medical School: Suny-Hlth Sci Ctr At Syracuse, Coll Of Med, Syracuse Ny 13210
Graduation Year: 1999

Data Provided by:
Lisa Mielniczuk, MD
25 Castleton St Apt 1
Jamaica Plain, MA
Specialties
Cardiology
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
Data Provided by:

Gene Tests in Sudden Cardiac Death Victims

Provided By:

SUNDAY, Nov. 15 (HealthDay News) -- Genetic testing of people who've suffered sudden unexplained death is an effective and cost-efficient way of identifying genetic mutations that may put surviving relatives at increased risk for potentially deadly heart rhythm disturbances, a new study suggests.

Genetic defects that can cause sudden cardiac death occur in 25 percent to 30 percent of victims of sudden unexplained death. The current recommended approach is for first-degree relatives of sudden unexplained death victims to undergo comprehensive cardiac testing.

In this study, U.S. researchers compared the results and costs of postmortem genetic/molecular autopsy testing in 146 sudden unexplained death cases and found that 40 of the victims (26.7 percent) had either a catecholaminergic polymorphic ventricular tachycardia mutation (18 people) or a long QT syndrome mutation (22 people). Both are known to cause sudden death.

The researchers then estimated the costs of testing the 584 relatives of the sudden unexplained death victims. The total cost of postmortem genetic testing, genetic confirmation testing of the 160 relatives of victims who tested positive for mutations, and cardiac tests for both relatives of mutation-positive and mutation-negative sudden unexplained death victims was $6.78 million.

In comparison, comprehensive cardiac testing for all 584 relatives of the sudden unexplained death victims, followed by directed genetic testing, would have been more than $7.7 million.

"With less than 150 sudden unexplained death cases, use of a cardiac channel molecular autopsy would be estimated to save almost $1 million indicating a much less expensive way of evaluating those left behind," study co-author David Tester, a senior research technologist at Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minn., said in a news release.

"If you identify a mutation in a sudden unexplained death victim, you can do a simple genetic test in first-degree relatives to assess their risk and perform a disorder-directed clinical evaluation rather than a full clinical evaluation. If a relative is negative for the causative mutation, they may not need to undergo further clinical evaluation at all, and that saves money," Tester explained.

The study was to be presented Sunday at the American Heart Association's annual meeting in Orlando, Fla.

More information

The U.S. National Heart, Lung, and Blood Institute has more about sudden cardiac arrest.

SOURCE: American Heart Association, news release, Nov. 15, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com